Charles Edward Wyzanski, Jr. (May 27, 1906 – September 3, 1986) was a United States federal judge.
Born in Boston, Massachusetts, Wyzanski received an A.B. from Harvard College in 1927 and an LL.B. from Harvard Law School in 1930. After entering private practice in Boston in 1930, he served as a law clerk to two judges of the United States Court of Appeals for the Second Circuit, with Augustus Noble Hand from 1930 to 1931, and, after briefly resuming private practice, with Learned Hand in 1932. Wyzanski then returned to private practice in Boston until 1933, when he became a solicitor of labor for the United States Department of Justice]]. From 1935 to 1937, he was a special assistant to the Attorney General in the Office of the Solicitor General. He was again in private practice in Boston from 1937 to 1941.
On December 1, 1941, Wyzanski was nominated by President Franklin D. Roosevelt to a seat on the United States District Court for the District of Massachusetts vacated by Hugh Dean McLellan. Wyzanski was confirmed by the United States Senate on December 16, 1941, and received his commission on December 19, 1941. He also served as a public member of the National Defense Mediation Board from 1941 to 1942. He held several teaching posts during his judgeship, serving as a lecturer in government at Harvard University from 1942 to 1943; lecturer in law at the Massachusetts Institute of Technology from 1949 to 1950; and lecturer in law at Stanford University from 1949 to 1951.
Wyzanski served as chief judge of the District of Massachusetts from 1965 to 1971, assuming senior status on September 1, 1971. He was a professor of law at Columbia University in 1974, and continued serving on the bench until his death, in 1986, in Boston.